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Acronym: EvoSCO<\/mark><\/strong><\/strong><\/h2>\n\n\n\n

Project code:<\/strong> 162\/31.07.2023. Funding contract no.<\/strong> 760238 \/ dated 28.12.2023<\/mark><\/p>\n\n\n\n

Implementation period:<\/strong> February 2024 \u2212 June 2026<\/mark><\/p>\n\n\n\n

Total project value:<\/strong> RON 6,513,908.24, equivalent to EUR 1,206,715.20, of which RON 5,999,998.14 is funded through PNRR<\/mark><\/p>\n\n\n\n

Title<\/strong><\/h2>\n\n\n\n

Adaptive laboratory evolution strategies to increase the lipid accumulation process in oleaginous microorganisms and microbial oil production using agroindustrial residues as substrates<\/em><\/strong><\/p>\n\n\n\n

Abstract<\/strong><\/h2>\n\n\n\n

Yarrowia lipolytica<\/em> is a species considered a model for the study of oleaginous yeasts and a source of neutral intracellular lipids. Currently, at an industrial scale, only polyunsaturated fatty acids of microbial origin are produced using genetically modified Y. lipolytica<\/em> strains, and their production cost remains high due to the low accumulation rate.<\/p>\n\n\n\n

Aim<\/strong><\/h2>\n\n\n\n

The aim of this project is to develop adaptive laboratory evolution (ALE) strategies for generating hyperproductive oleaginous strains. The methodology will be developed and initially applied to Y. lipolytica<\/em> strains and then extended to other oleaginous organisms of industrial interest, providing significant insights into the molecular evolutionary mechanisms associated with lipogenesis.<\/p>\n\n\n\n

Objectives<\/strong><\/h2>\n\n\n\n